糖尿病肾病的发病机制及其早期生物标志物的研究进展

Research Progress on Pathogenesis and Early Biomarkers of Diabetic Kidney Disease

糖尿病肾病(diabetic kidney disease, DKD)是糖尿病(diabetes mellitus, DM)常见的微血管并发症之一。近年来,人们逐渐认识到炎症在调节DKD过程中起重要的作用,炎症也被认为是DKD进展的一个重要驱动因素,未来应该从免疫炎症和细胞水平方面更加深入研究DKD的发病机制以及探索DKD早期生物标志物以利于早期诊断、早治疗、延缓肾功能衰竭。本文主要对DKD的发病机制及其早期生物标志物的作用作一综述,以期为DKD的早期诊断提供理论支撑。

Diabetic kidney disease (DKD) is one of the common microvascular complications of diabetes mellitus. In recent years, people have gradually realized that inflammation plays an important role in the regulation of DKD, and inflammation is also considered to be an important driving factor for the progression of DKD. In the future, more in-depth research should be conducted on the pathogenesis of DKD from the perspectives of immune inflammation and cellular level, as well as exploring early biomarkers for DKD to facilitate early diagnosis, treatment, and delay renal failure. This article mainly reviews the pathogenesis of DKD and the role of early biomarkers, in order to provide theoretical support for the early diagnosis of DKD.