从微生物–肠–脑轴分析焦虑、抑郁及睡眠障碍与炎症性肠病关系的研究进展

Research Progress on the Relationship among Anxiety, Depression, Sleep Disorders and Inflammatory Bowel Disease from the Microbiome-Gut-Brain Axis

炎症性肠病(IBD)是一种常见的慢性非特异性肠道炎症疾病,包括克罗恩病以及溃疡性结肠炎。随着我国人民生活习惯、饮食习惯的改变,近年来IBD在我国的发病率逐年升高,研究发现心理因素与IBD的疾病进展之间存在密切的关系,IBD患者焦虑、抑郁以及睡眠障碍的发生率较高。此外,肠屏障功能受损、肠道微生物群功能障碍以及肠道免疫功能异常等均在IBD发生发展过程中发挥着重要调控作用。本研究基于IBD患者心理因素以及微生物–肠–脑轴进行综述分析,从微生物–肠–脑轴分析焦虑、抑郁及睡眠障碍与炎症性肠病关系的研究进展。

Inflammatory bowel disease (IBD) is a common chronic nonspecific intestinal inflammatory disease, including Crohn’s disease and ulcerative colitis. With the change of people’s living habits and eating habits in China, the incidence of IBD in China has increased year by year in recent years. Studies have found that there is a close relationship between psychological factors and the disease progress of IBD, and the incidence of anxiety, depression and sleep disorders in patients with IBD is high. In addition, intestinal barrier dysfunction, intestinal microflora dysfunction and intestinal immune dysfunction all play an important regulatory role in the occurrence and development of IBD. Based on the psychological factors of patients with IBD and the microbial-intestinal-brain axis, this study analyzes the relationship between anxiety, depression, sleep disorders and inflammatory bowel disease from the microbial-intestinal-brain axis.