以抗氧化为策略改善皮肤光老化的研究进展

Research Progress on Improving Skin Photoaging through Antioxidant Strategies

光老化是指由于紫外线照射引起的以皮肤干燥、皱纹增多、色素沉积甚至可能诱发皮肤癌为主要特征,严重影响人们对美丽和健康的需求的皮肤外源性老化。因此缓解光老化成为当代医学的重要研究内容之一。紫外线通过多种机制影响光老化,其中以促进皮肤产生过量活性氧,直接损伤组织及引发相关信号通路为主要特征。以抗氧化为策略缓解或治疗光老化是目前研究的一个关键方向,主要包括不同类别的抗氧化剂及抗氧化活性物质的局部或全身使用。缓解由紫外线辐射引起的过度氧化应激,已成为今后深入研究抗光老化的一个关键方向。

Photoaging is exogenous skin aging caused by excessive ultraviolet (UV) radiation, which is manifested by dry skin, increased wrinkles, pigment deposition and even skin cancer, which seriously affects the aesthetic needs and health of people. Therefore, alleviating photoaging has become one of the important research contents of contemporary medicine. UV affects photoaging through a variety of mechanisms, which are mainly characterized by promoting the production of excess reactive oxygen species in the skin, directly damaging tissues and triggering related signaling pathways. Taking antioxidation as a strategy to alleviate or treat photoaging is a key direction of current research, mainly including the local or systemic use of different classes of antioxidants and antioxidant active substances. Alleviating the excessive oxidative stress induced by UV light has become a key direction for further research on anti photoaging in the future.