重组人脑利钠肽的临床应用进展

Application Progress of Recombinant Human Brain Natriuretic Peptide in Clinical Practice

重组人脑利钠肽(Recombinant Human Brain Natriuretic Peptide, rhBNP)是通过人工重组技术合成的一种外源性肽,可以发挥与内源性脑钠肽(Brain Natriuretic Peptide, BNP)相似生理作用,如促进肾脏排水排钠、扩张血管降低血压、减少心脏前后负荷、抑制肾上腺素系统从而延缓心肌重构和维持血流动力学稳定。自从rhBNP被纳入到心力衰竭防治指南以来,国内外对于其的研究不断加深,本文将简要介绍rhBNP的最新研究动态,以期为临床治疗提供借鉴。

Recombinant human brain natriuretic peptide (rhBNP) is an exogenous peptide synthesized through recombinant technology that can exert physiological effects similar to endogenous brain natriuretic peptide (BNP). These effects include promoting renal water and sodium excretion, dilating blood vessels to lower blood pressure, reducing cardiac preload and afterload, inhibiting the adrenergic system to delay myocardial remodeling, and maintaining hemodynamic stability. Since the inclusion of rhBNP in the guidelines for the prevention and treatment of heart failure, research on it has deepened both domestically and internationally. This article will briefly introduce the latest research dynamics of rhBNP, aiming to provide a reference for clinical treatment.