血管内皮生长因子与抑郁障碍相关性研究进展

Research Progress on Correlation between Vascular Endothelial Growth Factor and Depressive Disorder

抑郁障碍因其高发病率、长病程和高自杀风险而备受关注。近年来大量研究证明血管内皮生长因子(VEGF)在抑郁障碍的发生发展过程中起到一定作用。因此本文就VEGF与抑郁障碍间的关系进行综述,重点探讨了VEGF在神经系统发育、细胞保护、神经元活动调节等方面的作用,以及其在抑郁障碍患者中的表达情况。文章还强调目前仍需要更多深入研究以明确VEGF与抑郁障碍的关系,以探索VEGF在未来抗抑郁治疗策略中的潜在应用。

Depression disorder has garnered significant attention due to its high prevalence, prolonged course, and increased risk of suicide. Recent studies have demonstrated that Vascular Endothelial Growth Factor (VEGF) plays a role in the onset and progression of depression disorders. This article provides a comprehensive review of the relationship between VEGF and depression disorders, focusing on VEGF’s role in neural development, cell protection, and neuron activity regulation, as well as its expression in patients with depression disorders. The article also emphasizes the need for further in-depth research to clarify the relationship between VEGF and depression disorders and to explore the potential application of VEGF in future antidepressant treatment strategies.