T淋巴细胞在肿瘤中的研究进展

Research Progress of T Lymphocyte in Tumor

目的:介绍T淋巴细胞在肿瘤微环境中所发挥的免疫调节作用的研究现状。方法:查阅并总结国内外近年来有关肿瘤微环境中T淋巴细胞发生发展及预后相关性的基础和临床应用研究的相关文献并加以综述。结果:肿瘤微环境中T淋巴细胞具有明显的复杂性和多样性,免疫抑制环境的抑制性免疫细胞和发挥抗肿瘤作用的刺激性免疫细胞共同促进或抑制了癌症的发生和进展。结论:T淋巴细胞在肿瘤微环境中的确切作用仍有待进一步研究。随着相关的研究成果不断积累,更多的肿瘤患者将从免疫治疗中获益。

Objective: To introduce the research status of T lymphocytes in immunoregulatory role in tumor microenvironment. Methods: The basic and clinical studies on T lymphocyte development and prognosis in tumor microenvironment were reviewed. Results: There were obvious complexity and diversity of T lymphocytes in the tumor microenvironment. The inhibitory immune cells in the immunosuppressive environment and the stimulating immune cells in the anti-tumor environment jointly promoted or inhibited the occurrence and progression of cancer. Conclusion: The exact role of T lymphocytes in the tumor microenvironment remains to be further studied. With the accumulation of relevant research results, more cancer patients will benefit from immunotherapy.