迁移体的研究进展

Advances in Migrators Research

迁移体是一种新的胞外细胞器。当细胞发生定向迁移时,在细胞后面会出现回缩纤维,迁移体就位于回缩纤维末端或分叉处。当回缩纤维断裂,迁移体随之发生渗漏或者破裂,里面的内容物被释放到细胞外。作为一种胞外的膜性细胞器,迁移体可以将细胞的内容物运送到细胞外,分泌到胞浆或者被周围细胞吸收。研究证实,迁移体在细胞间的通讯、mRNA横向传递以及线粒体的质控方面有着重要作用。本篇综述总结了迁移体的发现过程、发生机制以及迁移体最新的研究进展。本综述还对迁移体的研究前景进行展望,希望能更进一步探究迁移体的作用。

Migrators are a new type of extracellular organelle. When cells undergo directed migration, retracted fibers appear behind the cells, and the migrating body is located at the end or fork of the retracted fibers. When the retracted fibers break, the migrating material leaks or ruptures, and the contents inside are released outside the cell. As an extracellular membranous organelle, migratory cells can transport cellular contents to the outside of the cell, secrete them into the cytoplasm, or be absorbed by surrounding cells. Research has confirmed that transfersomes play important roles in intercellular communication, mRNA lateral transmission, and mitochondrial quality control. This review summarizes the discovery process, mechanism of migration, and the latest research progress on migration. This review also looks forward to the research prospects of migration agents, hoping to further explore the role of migration agents.