内皮发育调节基因-1在2型糖尿病加重牙周炎机制中的研究进展

The Advancement of Research on Developmental Endothelial Locus-1 in the Pathogenesis of Periodontitis Exacerbated by Type 2 Diabetes Mellitus

牙周炎是成人牙齿脱落的主要原因,糖尿病是公认的牙周炎危险因素。2型糖尿病(type 2 diabetes mellitus, T2DM)牙周炎的致病机制尚未完全阐明。内皮发育调节基因-1 (DEL-1)是一种多功能蛋白,可调节包括牙周炎在内的炎症性疾病的不同阶段。本文通过回顾相关文献,综述DEL-1与T2DM牙周炎的相关性研究,旨在为研究T2DM加重牙周炎的可能机制以及T2DM牙周炎潜在治疗策略提供新的见解。

Periodontitis is a leading cause of tooth loss in adults, with diabetes being identified as a significant risk factor for its development. The exact pathogenesis of periodontitis in individuals with type 2 diabetes mellitus (T2DM) remains unclear. Developmental endothelial locus-1 (DEL-1) is a versatile protein involved in the regulation of various inflammatory diseases, including periodontitis. By reading the relevant literature, this paper reviews the relationship between DEL-1 and T2DM periodontitis, in order to provide new insights into the possible mechanism of T2DM aggravating periodontitis and the potential treatment strategy of T2DM periodontitis.