慢性HBV感染“灰区”的研究进展及展望

Research Progress and Prospects of Chronic Hepatitis B Virus Infection in Gray Zone

慢性乙型肝炎(CHB)构成了全球公共卫生领域的重大挑战。相当一部分CHB患者不属于传统定义的自然史分期的任一阶段,被认为处于“灰区”或“不确定期”。目前不同国家或地区的指南对“灰区”患者的管理策略仍存在争议,对慢性HBV感染“灰区”患者病理学特征、疾病进展风险的研究对于优化治疗策略、改善预后至关重要。本综述汇总了现有的研究成果,包括“灰区”患者的分布情况、肝组织病理学特点、疾病进展以及不同指南中的管理策略等,提出对“灰区”患者未来研究的展望。

Chronic Hepatitis B (CHB) presents a significant challenge in the realm of global public health. A considerable portion of CHB patients do not fit into any stage of the traditionally defined natural history and are considered to be in a “gray zone” or in an “indeterminate phase.” Currently, there is controversy regarding the management strategies for “gray zone” patients among different national or regional guidelines. Research into the pathological characteristics and risks of disease progression for patients with chronic HBV infection in the “gray zone” is crucial for optimizing treatment strategies and improving outcomes. This review compiles existing research findings, including the distribution of “gray zone” patients, pathological features of liver tissue, disease progression and management strategies outlined in various guidelines;and proposes future research directions for “gray zone” patients.