BDNF/TrkB信号通路在一氧化碳中毒迟发性脑病中的研究进展

Research Progress of BDNF/TrkB Signaling Pathway in Delayed Encephalopathy after Acute Carbon Monoxide Poisoning

一氧化碳中毒迟发脑病(DEACMP)的主要症状是认知功能障碍,这导致患者的日常生活能力出现下降,给患者、家庭乃至整个社会带来沉重的负担。目前DEACMP的发病机制不明,尚无特效的治疗方法,因此,明确DEACMP的发病原因并寻找有效的治疗策略已经成为临床研究的焦点。研究表明,DEACMP的发生与BDNF/TrkB信号通路有着紧密的联系。因此本文就近年来BDNF/TrkB信号通路在DEACMP中的研究进行综述。

The main symptom of delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is cognitive dysfunction, which leads to the decline of patients’ ability of daily living and brings a heavy burden to patients, families and even the whole society. At present, the pathogenesis of DEACMP is unknown, and there is no specific treatment. Therefore, it has become the focus of clinical research to clarify the pathogenesis of DEACMP and find effective treatment strategies. The research shows that the occurrence of DEACMP is closely related to BDNF/TrkB signal pathway. Therefore, this paper summarizes the research on BDNF/TrkB signal path in DEACMP in recent years.