桔梗汤治疗急性肺损伤的活性成分研究进展

Research Progress on Active Components of Platycodon grandiflorum Decoction in the Treatment of Acute Lung Injury

桔梗汤最早见于张仲景的《伤寒论》中治疗咽痛以及《金匮要略》治疗肺痈所导致的咳嗽,有清热解毒祛痰,利咽止咳排脓之效,而现代药理研究表明其有加号的抗炎、止咳化痰、抗菌、抗病毒的作用,常用于治疗咽喉部、肺部疾患。急性肺损伤是在临床上常见且死亡率较高的疾病,且目前缺乏特效的治疗药物和方案,而通过中医学进行辨证论治选取中药复方来进行防治ALI具有一定的疗效。研究表明,桔梗汤中的活性成分对肺部炎症损伤具有保护作用。本文从桔梗汤的中医源流、活性成分等角度对桔梗汤治疗ALI进行整理分析,为其对更多肺部疾病的治疗提供依据。

The Platycodon grandiflorum decoction was firstly seen in treating sore throat in Treatise on Febrile Diseases by Zhang Zhongjing and in treating cough caused by lung abscess in The Essentials of the Golden Chamber. It has the effect of clearing heat, detoxifying and removing phlegm, relieving pharynx and relieving cough and removing pus. Modern pharmacological researches show that it has the effect of anti-inflammation, relieving cough and reducing phlegm, antibacterial and antiviral. Acute lung injury is a clinically common disease with high mortality, and there is currently a lack of specific therapeutic drugs and programs. However, selecting traditional Chinese medicine compounds for prevention and treatment of ALI through syndrome differentiation and treatment in traditional Chinese medicine has certain curative effects. Studies have shown that the active ingredients in Platycodon grandiflorum soup have a protective effect on lung inflammatory damage. This article analyzes the treatment of ALI with Platycodon grandiflorum soup from the perspectives of its traditional Chinese medicine origin and active ingredients, providing a basis for the treatment of more lung diseases.