子宫内膜异位症发病机制研究进展

Research Progress on the Pathogenesis of Endometriosis

子宫内膜异位症(Endometriosis, EMs)简称内异症,是育龄期女性常见的多发病,其表现形式多样,易复发,易恶变,对女性的身体健康及生活质量造成极大的危害。尽管目前已有许多基础与临床研究对EMs的致病机理进行了深入的探索,但其发生发展的具体原因尚不明确。越来越多的研究证明EMs是与遗传、激素、免疫、炎症微环境等多重因素相互联系的复杂疾病,本文就近年来EMs在表观遗传、免疫炎症、激素等方面发病机制的研究作一综述。

Endometriosis (EMs) is a common and frequently occurring disease in women of childbearing age. Its lesions are extensive and diverse, and have invasiveness and metastasis similar to malignant tumors. It is highly recurrent and can also undergo malignant transformation, seriously affecting women’s health and quality of life. Although there have been numerous basic and clinical studies exploring the etiology and mechanism of EMs in recent years, there is still controversy over the exact etiology and pathogenesis of the development of EMs. More and more studies have shown that EMs are complex diseases that are interrelated with multiple factors such as genetics, hormones, immunity, and inflammatory microenvironment. This article reviews the recent research on the pathogenesis of EMs in epigenetics, immune inflammation, hormones, and other aspects.