摘要
哺乳动物的肝脏具有很强的再生潜能,损伤后可迅速再生以恢复原有细胞数量。这体现在生理状态下正常分化和病理状态下异常分化,其背后均是Wnt通路发挥核心作用。在肝脏疾病中被激活的Wnt/β-catenin通路起到扳机点的作用,调控下游各基因的表达。本文就Wnt通路在调控肝脏组织再生与分化过程中的影响作一综述,总结机体拮抗肝炎、肝纤维化和肝癌发生机制,为临床治疗肝脏疾病提供新靶点及治疗思路。
The mammalian liver has a strong regenerative potential and can regenerate rapidly after injury to restore the original number of cells. This is reflected in normal differentiation in physiological state and abnormal differentiation in pathological state, behind which Wnt pathway plays a core role. The Wnt/β-catenin pathway activated in liver disease acts as a trigger point, regulating the expression of downstream genes. In this paper, the effects of Wnt pathway on the regulation of liver tissue regeneration and differentiation were reviewed, and the mechanisms of antagonism against hepatitis, liver fibrosis and liver cancer were summarized, providing new targets and therapeutic ideas for clinical treatment of liver diseases.
出处
《临床医学进展》
2024年第5期1822-1827,共6页
Advances in Clinical Medicine
