Fibulin-5与肿瘤关系的研究进展

Advances in the Study of the Relationship between Fibulin-5 and Tumours

细胞外基质(Extracellular matrix, ECM)在组织分化和器官发育中起关键作用。其通过细胞–基质和细胞之间的相互作用为周围细胞提供结构支持。作为基质细胞糖蛋白的一员,纤维蛋白5 (Fibulin-5, FBLN5)存在于弹性蛋白表达丰富的组织中,参与维持基底膜、弹性纤维和疏松结缔组织的结构完整性与稳定。在当前的研究中,多数学者表示FBLN5表达水平的改变与许多肿瘤的进展相关,此外,FBLN5的表达水平也会影响细胞的生长,转移以及患者的预后。其可能成为一个良好的早期诊断和判断预后的指标。本文现就FBLN5的结构、功能和作用机理作一综述。

The extracellular matrix plays a key role in tissue differentiation and organ development. It provides structural support to surrounding cells through cell-matrix and cell-cell interactions. As a member of matrix cell glycoproteins, fibronectin-5 is present in elastin-expressing-rich tissues and is involved in maintaining the structural integrity and stability of basement membranes, elastic fibres and loose connective tissues. In the current study, most scholars indicated that altered FBLN5 expression levels are associated with the progression of many tumours, and in addition, FBLN5 expression levels affect cell growth, metastasis, and patient prognosis. It may become a good indicator for early diagnosis and judgement of prognosis. In this paper, we now review the structure, function and mechanism of action of FBLN5.