细菌外膜囊泡在抗肿瘤中的研究进展

Research Progress of Bacterial Outer Membrane Vesicles in Anti-Tumor Therapy

肿瘤是困扰全球健康的主要问题之一,如何克服目前所使用的治疗手段中的限制,是亟需解决的问题关键。细菌在分子机制方面得到了充分的证实,已被广泛的考虑在肿瘤治疗中的应用。外膜囊泡(Outer membrane vesicles, OMVs)是由革兰氏阴性菌分泌的双层脂质纳米囊泡。OMVs含有多种生物分子,是细菌与细菌、环境和宿主等交流的重要介质,因此它们可能成为抗肿瘤的有效的方案。本文综述了OMVs的结构、发生机制和生物学功能,此外,本文还重点关注了OMVs在抗肿瘤方面的应用进展。

Tumor is one of the major global health issues, and overcoming the limitations of currently used treatment methods is a crucial issue that needs to be addressed urgently. Bacteria, with their well-established molecular mechanisms, have been widely considered for application in tumor therapy. Outer membrane vesicles (OMVs) are double-layer lipid nanovesicles secreted by Gram-negative bacteria. OMVs contain a variety of biomolecules and are important mediators of communication between bacteria, the environment, and the host, making them potentially effective candidates for anti-tumor therapy. This article reviews the structure, biogenesis, and biological functions of OMVs. In addition, it focuses on the progress of OMVs in anti-tumor applications.