铁死亡与慢性心力衰竭

Ferroptosis and Chronic Heart Failure

心血管病“后时代”疾病–慢性心力衰竭发病率在逐年升高,报道显示全球约有超过2600万人受到CHF的影响,高病死率和高发病率导致诊断后5年内生存率不足50%。近年来,新型的程序性死亡–铁死亡在慢性心力衰竭心肌损伤中发挥了重要作用,越来越多的研究发现,铁死亡在心血管系统、肾脏系统等疾病中发挥重要作用;铁死亡介导的氧化应激在慢性心力衰竭中起重要作用。氢分子具有抗氧化、减少心肌细胞死亡的作用,可减缓慢性心力衰竭患者心肌死亡。

The incidence of chronic heart failure (CHF), a disease of the “latter era” of cardiovascular disease, is increasing year by year, and reports show that more than 26 million people worldwide are affected by CHF, with a high mortality and morbidity rate that leads to a survival rate of less than 50% within 5 years after diagnosis. In recent years, a new type of programmed death, Ferroptosis, has played an important role in myocardial injury in chronic heart failure. More and more studies have found that iron death plays an important role in diseases of the cardiovascular system, renal system, and other diseases;and that iron death-mediated oxidative stress plays an important role in chronic heart failure. Hydrogen molecules have antioxidant and cardiomyocyte death-reducing effects, which can slow down myocardial death in patients with chronic heart failure.