基于分类组学的子痫前期病因研究进展

Research Progress on Etiology of Preeclampsia Based on Taxonomy

子痫前期是孕产妇死亡的首要原因之一,病因复杂并且累及多个系统。基因组学研究提示子痫前期具有遗传基因易感性,DNA甲基化失调可能导致子宫螺旋动脉侵袭缺乏。转录组学研究提示miRNA调节血管生成途径从而导致子痫前期发病。蛋白质组学重新将子痫前期分为“胎盘”、“母体抗胎儿排斥反应型”、“细胞外基质相关”、“代谢”四个亚类。代谢组学讨论了子痫前期患者氨基酸、脂肪酸代谢变化的潜在影响。微生物组学揭示了肠道、阴道微生物菌群诱发妊娠期高血压的理论机制。而中西医结合研究也从传统中医理论中探寻病机,以更好地寻找子痫前期的病因。

Preeclampsia is one of the leading causes of maternal death. The etiology is complex and involves multiple systems. Genomics studies suggest that preeclampsia has genetic susceptibility, and DNA methylation disorders may lead to a lack of uterine spiral artery invasion. Transcriptome studies suggest that miRNAs regulate the angiogenesis pathway leading to the pathogenesis of preeclampsia. Proteomics re-divided preeclampsia into four subcategories: “placenta”, “maternal anti-fetal rejection”, “extracellular matrix-related”, and “metabolism”. Metabolomics discussed the potential effects of changes in amino acid and fatty acid metabolism in patients with preeclampsia. Microbiome reveals the theoretical mechanism of intestinal and vaginal microbial flora inducing gestational hypertension. The study of integrated traditional Chinese and Western medicine also explores the pathogenesis from the theory of traditional Chinese medicine to better find the cause of preeclampsia.