炎症生物标记物对急性胰腺炎病情评估及预测价值分析

Analysis of the Evaluation and Predictive Value of Inflammatory Biomarkers in Acute Pancreatitis

目的:探讨急性胰腺炎(AP)患者入院初期外周血中炎症指标,包括血小板淋巴细胞比值(PLR)、中性粒细胞淋巴细胞比值(NLR)及全身免疫炎症指数(SII),对疾病预后及预测价值评估。方法:选取康复大学青岛中心医院2023年1月至2023年12收治的136例确诊为AP患者为研究对象,收集AP患者急诊入院24小时内血常规结果及各类比值结果,根据患者疾病轻重程度进行分组,以受试者工作特征曲线(ROC)分析外周血PLR、NLR、SII水平对急性胰腺炎预后的预测价值评估。结果:136例AP患者中,轻症组为118例(86.76%),非轻症组为18例(13.24%)。两组患者临床资料中白细胞计数、中性粒细胞计数、血小板计数、PLR、NLR及SII结果差异具有统计学意义(p < 0.05)。ROC结果分析示,PLR、NLR及SII指数的曲线下面积(AUC)分别为(0.8051, 0.8185, 0.9195),灵敏度分别为(75.00, 83.33, 91.67),特异度分别为(69.49, 63.56, 81.36)。结论:非轻症急性胰腺炎患者组入院初期外周血中PLR、NLR及SII指数较轻症患者组高,外周血PLR、NLR及SII指数水平具有一定的早期重症预测效能。

Objective: Exploring inflammatory markers in the peripheral blood of patients with acute pancreatitis (AP) during the initial admission period, including platelet lymphocyte ratio (PLR), neutrophil lymphocyte ratio (NLR), and Systemic Immune Inflammation index (SII), to evaluate their prognostic and predictive value for the disease. Method: 136 patients diagnosed with AP admitted to Qingdao Central Hospital of Rehabilitation University from January 2023 to December 2023 were selected as the research subjects, collect blood routine results and various ratio results of AP patients within 24 hours of emergency admission, group them according to the severity of the disease, and evaluate the predictive value of peripheral blood PLR, NLR, and SII levels on the prognosis of acute pancreatitis using receiver operating characteristic curve (ROC) analysis. Result: Among 136 patients with AP, there were 118 cases (86.76%) in the mild group and 18 cases (13.24%) in the non mild group. The clinical data of the two groups of patients showed statistically significant differences in white blood cell count, neutrophil count, platelet count, PLR, NLR, and SII results (p < 0.05). The ROC result analysis showed that the area under the curve (AUC) of PLR, NLR, and SII index were (0.8051, 0.8185, 0.9195), sensitivity were (75.00, 83.33, 91.67), and specificity were (69.49, 63.56, 81.36), respectively. Conclusion: The PLR, NLR, and SII index in the peripheral blood of patients with non mild acute pancreatitis were higher than those of patients with mild acute pancreatitis at the initial admission stage. The levels of PLR, NLR, and SII index in peripheral blood have certain predictive power for early severe illness.