microRNAs在急性心肌梗死诊治中的研究进展

Research Progress of microRNAs in Diagnosis and Treatment of Acute Myocardial Infarction

急性心肌梗死(acute myocardial infarction, AMI)目前是我国主要引起致残率和致死率的重大疾病,其诊断主要依靠心电图变化和心肌肌钙蛋白,心肌肌钙蛋白的增高可以提示AMI,但并非心肌所特有,且肌钙蛋白的升高平均时间是AMI发病后4小时,对于早期发现AMI患者有一定局限性。近年来关于microRNA的研究表明,其在AMI的诊断和治疗中具有重要意义。本文在前人研究的基础上,总结microRNA在心肌梗死中的研究进展,并为后面的研究提供理论指导。

Acute myocardial infarction (AMI) is now a major disease that mainly causes disability and mortality in China, and its diagnosis mainly relies on electrocardiogram changes and cardiac troponin, the increase of cardiac troponin can suggest AMI, but it is not unique to the myocardium, and the average time of troponin elevation is 4 hours after the onset of AMI, for the average time of Troponin elevation is 4 hours after the onset of AMI, which is a limitation for early detection of AMI patients. In recent years, studies on microRNAs have shown their significance in the diagnosis and treatment of AMI. This paper summarizes the research progress of microRNA in myocardial infarction based on previous studies and provides theoretical guidance for later studies.