预后营养指数联合尿素–肌酐比值对单倍体造血干细胞移植患者移植预后的评估价值

The Value of Prognostic Nutritional Index Combined with Urea-Creatinine Ratio in Assessing the Prognosis of Transplantation in Patients Undergoing Haploidentical Stem Cell Transplantation

本研究探讨了移植前作为潜在的预测指标,预后营养指数(PNI)和尿素–肌酐比值(UCR)对单倍体造血干细胞移植(HID-HSCT)患者结局的影响。通过对55例行HID-HSCT患者移植前的临床数据进行了回顾性分析。采用生存曲线比较不同组别的总生存期(OS)和无进展生存期(PFS)。研究发现与低PNI组(PNI P = 0.0394)和PFS (P = 0.0417)更好。两组的3年OS分别为34.6%和74.1%。与高UCR组(UCR ≥ 54.1)相比,低UCR组(UCR P P P = 0.047)是影响患者OS的独立风险因素。结论:移植前高PNI、高UCR、低PNI + 高UCR的患者行HID-HSCT预后较差。

This study investigated the impact of pretransplantation, as potential predictors, prognostic nutritional index (PNI) and urea-creatinine ratio (UCR) on the outcome of haploidentical hematopoietic stem cell transplantation (HID-HSCT) patients. Clinical data from 55 HID-HSCT patients before transplantation were analyzed retrospectively. Survival curves were used to compare overall survival (OS) and progression-free survival (PFS) in different groups. It was found that OS (P = 0.0394) and PFS (P = 0.0417) were better in the high PNI group (PNI ≥ 38.6) compared to the low PNI group (PNI P P P = 0.047) was an independent risk factor affecting patients’ OS. Conclusion: Patients with high PNI, high UCR, and low PNI + high UCR before transplantation underwent HID-HSCT with a poorer prognosis.