姜黄素治疗神经胶质瘤的研究进展

Research Progress of Curcumin in the Treatment of Glioma

姜黄素是一种具抗炎、抗菌、抗氧化和抗肿瘤等特性的天然中药提取物,在中枢神经系统中,姜黄素具有显著的抗肿瘤作用,尤其是在治疗神经胶质瘤方面。大量研究表明,姜黄素可以显著抑制神经胶质瘤的发生发展,在这篇综述中,我们阐述了姜黄素在抑制肿瘤血管生成、抑制肿瘤细胞增殖、诱导细胞凋亡、抑制肿瘤细胞迁移和侵袭、停滞细胞周期等方面对抗神经胶质瘤的分子机制,揭示了姜黄素的开发利用可能是治疗神经胶质瘤的一个新兴研究领域。

Curcumin is a natural Chinese medicine extract with anti-inflammatory, antibacterial, antioxidant, and anti-tumor properties. In the central nervous system, curcumin has a significant anti-tumor effect, especially in the treatment of glioma. A large number of studies have shown that curcumin can significantly inhibit the occurrence and development of glioma. In this review, we explained that curcumin can inhibit tumor angiogenesis, inhibit tumor cell proliferation, induce apoptosis, and inhibit tumor cell migration and invasion, cell cycle arrest and other aspects of the molecular mechanism against glioma. It is revealed that the development and utilization of curcumin may be an emerging research field in the treatment of glioma.