“二仙”四种主要入血成分与雌激素受体之间作用的研究进展

Research Progress on the Interaction between the Four Main Components of “Er-Xian” and Estrogen Receptor

“二仙”即仙茅、仙灵脾(又名淫羊藿),是传统的温肾壮阳之品,其具有雌激素样作用。淫羊藿苷(ICA)、朝藿定A(EA)、淫羊藿次甙II (ICS-II)、苔黑酚葡萄糖苷(OG)作为“二仙”提取物灌胃SD大鼠后的4种入血成分,亦具有雌激素样作用。本文梳理了近年来国内外已报道的“二仙”4种入血成分相关文献,综述了淫羊藿苷、朝藿定A、淫羊藿次苷II、苔黑酚葡萄糖苷与雌激素受体之间作用的研究进展,为相关领域研究者进一步研究该类药提供参考。

”Ee-xian” (Curculigo orchioides Gaertn and Epimedium) is the traditional warm kidney aphrodisiac product, which has estrogen-like effect. Icariin (ICA), Epimedin A (EA), icariside II (ICS-II) and Orcinol glucoside (OG), as the four components of “Erxian” extract after intragastric administration in SD rats, also have estrogen-like effects. In this paper, the literatures related to the four blood components of “Erxian” reported at home and abroad in recent years were reviewed, and the research progress on the interaction between icariin, icaridine A, icariin II, orlichenol glucoside and estrogen receptor was reviewed, so as to provide references for researchers in related fields to further study this drug.