肾动脉消融去交感神经术治疗高血压研究进展

Study Progress on Renal Sympathetic Denervation in the Treatment of Hypertension

高血压目前是导致心脑血管疾病的主要危险因素之一,同时也是成人全因死亡的主要危险因素,包括药物依从性差以及药物不耐受等多种原因导致血压不达标造成的靶器官损害直接危害着人类的健康。研究发现肾脏交感神经的过度激活是导致高血压发生的相关机制之一,鉴于肾交感神经在血压的神经源性控制和高血压的病理生理中的关键作用,肾动脉去交感神经作为高血压治疗的一种方式已被研究了多年。对于肾动脉去交感神经术的临床治疗效果仍存在许多争议。本文就肾动脉去交感神经术治疗高血压的相关研究及进展进行综述。

Hypertension is currently one of the main risk factors for cardiovascular and cerebrovascular diseases, and it is also a major risk factor for all-cause mortality in adults. Target organ damage caused by blood pressure non-compliance, including poor medication adherence and drug intolerance, directly endangers human health. Studies have found that the overactivation of renal sympathetic nerves is one of the mechanisms leading to the development of hypertension. Given the key role of renal sympathetic nerves in neurogenic control of blood pressure and the pathophysiology of hypertension, renal artery denervation as a treatment for hypertension has been studied for many years. There are still many controversies regarding the clinical efficacy of renal artery denervation. This article reviews the relevant research and progress of renal artery denervation in the treatment of hypertension.