循环miRNA在预测非小细胞肺癌转移中的研究进展

Study Progress of Circulating miRNA for Predicting Metastasis in Non-Small Cell Lung Cancer

肺癌是全球范围内癌症相关死亡的主要原因,非小细胞肺癌(NSCLC)是最常见的病理类型,远处转移是NSCLC相关死亡的重要原因。因此,有必要寻找新型分子生物标志物,识别具有高度转移风险的NSCLC患者,以进行更密切的随访和制定更个性化的治疗方法,从而改善NSCLC患者的生存。由于循环microRNA (miRNA)的诸多优点,如易获取性、高度稳定性、特异性、敏感性,故其作为预测NSCLC转移的分子生物标志物具有广阔的应用前景。本文对循环miRNA作为预测NSCLC转移生物标志物的作用进行了综述,以期为改善NSCLC的预后提供新的策略。

Lung cancer is the leading cause of cancer-related deaths worldwide, and non-small cell lung cancer (NSCLC) is the most common pathological type. The main cause of NSCLC-related deaths is distant metastasis. Therefore, it is necessary to find novel biomarkers to identify NSCLC patients with high metastatic risk for closer follow-up and more personalized treatment, thereby improving the survival of NSCLC patients. Because of the advantages, such as easy accessibility, high stability, specificity, and sensitivity, circulating microRNAs (miRNAs) have broad application prospects as molecular biomarkers for predicting NSCLC metastasis. In this review, the role of circulating miRNAs as biomarkers in predicting NSCLC metastasis is reviewed, in order to provide a new strategy for improving the prognosis of NSCLC.