基于数据挖掘中医药治疗溃疡性结肠炎动物实验的用药规律研究

Study on the Medication Law of Traditional Chinese Medicine in Treating Animal Experiments of Ulcerative Colitis on Data Mining

目的:研究分析用中药治疗溃疡性结肠炎动物实验的用药规律。方法:通过对中国知网(CNKI)、万方数据库(WANFANGDATE)及维普中文期刊数据库(VIP)治疗溃疡性结肠炎的动物实验所用中药进行筛选,通过“古今医案云平台”对中药的四气五味、性味归经进行数据分析。结果:最终纳入处方90首,包含中药149味,主归肝、脾、肺经,其中使用频次较高的药物是黄连、甘草、茯苓、黄芩、白及等;结论:溃疡性结肠炎动物实验的治疗以清热解毒为主,辅以健脾、行气、活血化瘀。本研究为溃疡性结肠炎的临床用药提供了参考。

Objective: To study and analyze the medication law of traditional Chinese medicines used in animal experiments for the treatment of ulcerative colitis. Methods: The Chinese herbal medicines used in animal experiments for ulcerative colitis were screened in CNKI, WANFANGDATE and VIP databases, and the data of the four-qi and five-flavors and the attributes of the Chinese herbal medicines were analyzed by the “Ancient and Modern Medical Case Cloud Platform”. Results: 90 prescriptions were included, containing 149 flavors of traditional Chinese medicines, which were mainly classified into the liver, spleen and lung meridians, and the most frequently used medicines were Huang Lian, Gan Cao, Poria, Scutellaria baicalensis, Bai Ji, etc. Conclusion: The treatment of ulcerative colitis in animal experiments is based on clearing away heat and removing toxins, and is supplemented by strengthening the spleen, promoting circulation of qi, and activating blood circulation and removing blood stasis. This study provides a reference for the clinical medication of ulcerative colitis.