孟德尔随机化在COPD与合并症研究中的应用

Application of Mendelian Randomization in the Study of COPD and Comorbidities

疾病的病因对于正确理解疾病是必不可少的,也是预防和治疗疾病的关键。孟德尔随机化,被称为大自然的随机对照试验,正被广泛应用于探索疾病的病因。本文旨在综述该方法在慢性阻塞性肺疾病(COPD)领域的应用,为COPD的因果关联研究提供新的思路。

The causes of disease are essential for a proper understanding of disease and are crucial for its prevention and treatment. Mendelian randomization, known as nature’s Randomized Controlled Trial, is being widely used to explore the etiology of diseases. The aim of this paper is to review the application of this method in the field of chronic obstructive pulmonary disease (COPD) and to provide new ideas for the study of causal associations in COPD.