肝细胞癌的诊断及治疗进展

Advances in Diagnosis and Treatment of Hepatocellular Carcinoma

肝细胞癌是我国临床上常见的恶性肿瘤,占原发性肝癌75%~85%,极高的肿瘤致死率严重威胁国民的身体健康。影像学检查及肿瘤标志物的监测有利于肝细胞癌的诊断,早期肝细胞癌的主要治疗方式为肝切除术,对于晚期肝细胞癌,肝移植是最有效的治疗,近几年,以靶向治疗和免疫治疗为主的系统治疗方式在晚期肝细胞癌的治疗中起到了一定的成效。靶向治疗联合免疫治疗可有效延长患者生存时间,改善预后。新的抗肝细胞癌作用靶点也是该领域近年来的研究热点。本文将总结了肝细胞癌的临床诊断及治疗方法的研究进展,为临床肝细胞癌患者的诊治提供理论依据。

Hepatocellular carcinoma is a common malignant tumor in clinical practice in China, accounting for about 75%~85% of primary liver cancer. Its’ extremely high tumor mortality rate seriously threatens the life and health of the people. Imaging examination and tumor marker monitoring are helpful for the diagnosis of hepatocellular carcinoma, the main treatment for early hepatocellular carcinoma is liver resection. For advanced hepatocellular carcinoma, liver transplantation is the most effective treatment. In recent years, targeted therapy and immunotherapy have played a certain role in the treatment of advanced hepatocellular carcinoma. Targeted therapy combined with immunotherapy can effectively prolong patient survival time and improve prognosis. New targets for anti-hepatocellular carcinoma have also been a research hotspot in this field in recent years. This article will summarize the research progress of clinical diagnosis and treatment methods for hepatocellular carcinoma, providing theoretical basis for the diagnosis and treatment of hepatocellular carcinoma patients.