艾司氯胺酮在改善外科患者围术期焦虑和抑郁中作用的研究进展

Research Progress of Esketamine in Improving Perioperative Depression and Sleep Quality

围术期焦虑和抑郁是临床常见且严重的心理问题,尤其是术前已被确诊为焦虑和抑郁的患者。艾司氯胺酮是一种N-甲基-D-天冬氨酸(N-methyl-D-aspartic, NMDA)受体拮抗剂,已被证明可通过直接靶向谷氨酸能神经系统快速改善抑郁症状和自杀意念。本文就近年来有关艾司氯胺酮在改善外科患者围术期焦虑和抑郁中的作用进行综述与总结,为改善患者的临床预后提供参考。

Esketamine is an N-methyl-D-aspartic acid (NMDA) receptor antagonist, which can play the role of anesthesia, analgesia and anti-negative emotions. It is a new clinical anesthetic. During the perioperative period, patients often suffer from depression and poor sleep quality due to nervousness and fear of pain, which is not conducive to the operation and postoperative recovery. Esketamine has a positive effect on anti-depression and improving sleep quality during perioperative period. This paper analyzes and summarizes the clinical application of estaketamine in relieving depression and improving sleep quality in recent years, so as to provide basis for rational use of drugs in clinic.