孕激素受体在非妇产科应用的研究进展

Research Progress on the Application of Progesterone Receptor Innon-Obstetrics and Gynecology

孕激素是人体重要的甾体激素,其生物学效应由多个受体介导,包括经典的核受体PRA、PRB,和非经典的膜受体(分为mPRα、mPRβ、mPRγ)和孕激素受体膜组分(分为PGRMC1和PGRMC2)。孕激素受体是女性生殖组织中的重要调节因子,其在妇产科领域的作用机制已被深入研究,而孕酮介导的非生殖作用较少被探索。本研究综述了近十年孕激素受体在神经系统(包括创伤性脑损伤、阿尔兹海默症、眼科等)、消化系统(包括胃肠道、肝胆、胰腺)、呼吸系统、循环系统、泌尿系统、内分泌系统、运动系统领域发挥作用的研究进展,总结了孕激素受体在非生殖器官生物学作用的新见解。

Progesterone is an important steroid hormone in human body, and its biological effects are mediated by several receptors, including classical nuclear receptors PRA, PRB, non-classical membrane receptors (divided into mPRα, mPRβ, mPRγ) and progesterone receptor membrane components (divided into PGRMC1 and PGRMC2). Progesterone receptor is an important regulatory factor in female reproductive tissue, and its mechanism of action in the field of obstetrics and gynecology has been deeply studied, while the non-reproductive effects of progesterone have been less explored. This study reviewed the recent research progress on the role of progesterone receptors in the nervous system (including traumatic brain injury, Alzheimer’s disease, ophthalmology, etc.), digestive system (including gastrointestinal tract, liver and gallbladder, pancreas), respiratory system, circulatory system, urinary system, endocrine system, motor system, and summarized new insights on the biological role of progesterone receptors in non-reproductive organs.