清肺化痰汤治疗重症缺血性脑梗死合并卒中相关性肺炎患者临床效果观察研究

Clinical Study on the Efficacy of Qingfei Huatan Decoction in Treating Severe Ischemic Stroke Patients with Stroke-Associated Pneumonia

目的:研究清肺化痰汤治疗重症缺血性脑梗死合并卒中相关性肺炎患者临床效果观察研究。方法:选取2021.01~2022.12.31在海南医学院第二附属医院神经内科重症监护室收治的120名重症缺血性脑梗死合并卒中相关性肺炎患者相关临床资料,常规治疗组包含60例患者(对照组),在常规治疗上加用清肺化痰汤治疗患者60例(观察组),比较两组患者在经过1周治疗后的NIHSS评分、CPIS评分PCT、CRP变化。结果:两组经过治疗后,NIHSS评分及CPIS评分均较前下降,观察组CPIS评分下降更明显,差异有统计学意义(P < 0.05)。两组PCT及CRP均较治疗前下降,观察组PCT下降较对照组明显,差异有统计学意义(P < 0.05)。结论:清肺化痰汤用于重症缺血性脑梗死合并卒中相关性肺炎患者疗效可靠,对患者的预后有一定的帮助,有一定的临床应用价值,值得临床推广使用。

Objective: This study aims to explore the clinical effectiveness of Qingfei Huatan Decoction in managing patients with severe ischemic cerebral infarction complicated by stroke-associated pneumonia. Methods: The clinical data of 120 severe ischemic cerebral infarction patients with stroke-associated pneumonia admitted to the neurological intensive care unit of the Second Affiliated Hospital of Hainan Medical University from January 2021 to December 2022 were selected. Sixty patients received conventional treatment (control group), while another 60 patients received Qingfei Huatan Decoction in addition to conventional treatment (observation group). The NIHSS scores, CPIS scores, PCT, and CRP changes were compared between the two groups after 1 week of treatment. Results: After the treatment, both NIHSS and CPIS scores decreased in both groups. However, the CPIS scores in the observation group showed a more significant reduction, indicating a statistically significant difference (P < 0.05). Additionally, PCT and CRP levels in both groups decreased compared to pre-treatment values, with a more notable decline in PCT in the observation group, also exhibiting a statistically significant difference (P < 0.05). Conclusion: Qingfei Huatan Decoction has demonstrated reliable therapeutic efficacy in treating patients with severe ischemic cerebral infarction complicated by stroke-associated pneumonia, providing valuable assistance to patients’ recovery prognosis. Therefore, it holds significant clinical application value and merits further promotion and utilization in clinical practice.