肺炎支原体肺炎患儿外周血NST水平与病情严重程度的相关性研究

Study on the Correlation between NST Levels in Peripheral Blood and the Severity of Mycoplasma Pneumoniae Pneumonia in Children

目的:探讨肺炎支原体肺炎(mycoplasma pneumoniae pneumonia, MPP)患儿外周血中性杆状核粒细胞(neutrophilic stab granulocyte, NST)水平与病情严重程度的相关性。方法:选取2023年9月~2024年2月陕西省人民医院152例肺炎支原体肺炎患儿为研究对象,根据病情分为轻症组(n = 100)和重症组(n = 52)。比较两组外周血NST水平。采用Spearman相关性检验分析外周血NST与C-反应蛋白(C-reactive protein, CRP)、乳酸脱氢酶(lactate dehydrogenase, LDH)、D-二聚体(D-dimer, D-D)、降钙素原(procalcitonin, PCT)水平的相关性。结果:重症组患儿外周血NST、CRP、LDH、D-D和PCT水平显著高于轻症组,差异具有统计学意义(均P r = 0.373, P r = 0.266, P r = 0.473, P < 0.05)水平呈正相关。结论:重症肺炎支原体肺炎患儿外周血NST水平升高,与肺炎支原体肺炎疾病病情严重程度有关。

Objective: To investigate the correlation between the level of neutrophilic stab granulocyte (NST) in peripheral blood of mycoplasma pneumoniae pneumonia (MPP) and the severity of the disease. Methods: 152 children with mycoplasma pneumoniae pneumonia in Shaanxi Provincial People’s Hospital from September 2023 to February 2024 were selected as the study object. They were divided into mild group (n = 100) and severe group (n = 52) according to their disease conditions. The levels of NST in peripheral blood of the two groups were compared. Spearman correlation test was used to analyze the correlation between NST and C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer (D-D) and procalcitonin (PCT) levels were evaluated. Results: The levels of NST, CRP, LDH, D-D and PCT in peripheral blood of children in severe group were significantly higher than those in mild group, with statistical significance (all P r = 0.373, P r = 0.266, P r = 0.473, P < 0.05) levels in the severe group. Conclusions: The increase of NST level in peripheral blood of children with severe mycoplasma pneumoniae pneumonia is related to the severity of the disease.