丹参制剂治疗冠心病作用机制及不良反应的研究进展

Research Progress on Mechanism of Action and Adverse Reactions of Salvia miltiorrhiza Preparations in the Treatment of Coronary Heart Disease

丹参制剂是临床上治疗心脑血管疾病最常用的中药制剂之一,具有调节血脂,扩张血管,抗动脉粥样硬化,抗血栓形成等作用。随着医药工业的发展,丹参制剂及剂型在不断创新和丰富,除了传统汤剂之外,更有胶囊、蜜丸、片剂、注射剂等,随着临床上的普及使用,有关丹参类药物不良反应的报道也日益增多。本文主要综述了近年来丹参制剂对于冠心病的药理作用以及不良反应,可为现代中药制剂的开发提供重要的参考依据。

Danshen preparations are one of the most commonly used traditional Chinese medicine formulations in clinical practice for treating cardiovascular and cerebrovascular diseases. They have effects such as regulating blood lipids, dilating blood vessels, anti-atherosclerosis, and anti-thrombosis. With the development of the pharmaceutical industry, Danshen preparations and formulations are continuously innovating and diversifying. In addition to traditional decoctions, there are also capsules, pills, tablets, injections, and more. As the clinical use becomes more widespread, reports of adverse reactions related to Danshen-like drugs are increasing. This article mainly reviews the pharmacological effects and adverse reactions of Danshen preparations on coronary heart disease in recent years, providing important reference basis for the development of modern Chinese medicine formulations.