阿尔茨海默病与肠道微生物群相关性的研究进展

Research Progress on the Correlation between Alzheimer’s Disease and Intestinal Microbiota

阿尔茨海默病是一种以进行性认知功能障碍为特征的神经系统退行性疾病,近年来的研究发现,阿尔茨海默病的发生与肠道微生物群密切相关,肠道微生物群失调可能通过介导神经炎症、淀粉样蛋白异常聚集和血脑屏障通透性受损等方面影响阿尔茨海默病的发生。该文围绕肠道微生物群与阿尔茨海默病的关系以及目前通过调节肠道微生物群在治疗阿尔茨海默病中的应用效果进行综述,以期为阿尔茨海默病的临床预防和治疗策略提供新的依据。Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive impairment. Recent studies have found that the occurrence of AD is closely related to the intestinal microbiota. Intestinal microbiome dysbiosis may affect the occurrence of AD by mediating neuroinflammation, abnormal amyloid protein aggregation, and impaired blood-brain barrier permeability. This paper reviews the relationship between AD and intestinal microbiota and the current application effect of AD by regulating intestinal microbiota to offer a new basis for the clinical prevention and treatment of AD.