GSDMB参与恶性肿瘤的研究进展

Research Progress of GSDMB Involved in Malignant Tumors

细胞焦亡是一种炎症性程序性死亡方式,是一种有别于传统的坏死、凋亡等的新型细胞死亡方式,主要由成孔蛋白Gasdermin (GSDM)家族介导。活化的半胱氨酸天冬氨酸特异性蛋白酶(caspase)切割Gasdermin家族成员释放N端结构域在胞膜上打孔,从而导致细胞肿胀破裂死亡。Gasdermin B (GSDMB)属于Gasdermin (GSDM)家族,具有促肿瘤或抗肿瘤作用。在肿瘤细胞的相关研究中发现,GSDMB在乳腺癌、胃癌、肝癌、宫颈癌和结肠癌等癌细胞中高表达。因此,学者们认为GSDMB可能作为癌基因参与了癌症的进展和转移。本文综述了GSDMB在各种恶性肿瘤中的作用,以期为肿瘤的临床诊断、治疗及预后提供新的思路。Pyroptosis is an inflammatory programmed cell death, which is different from traditional necrosis and apoptosis. It is mainly mediated by the poreforming protein Gasdermin (GSDM) family. Activated caspases cleave Gasdermin family members to release N-terminal domains that punch holes in the cell membrane, leading to cell swelling, rupture and death. Gasdermin B (GSDMB) belongs to the Gasdermin (GSDM) family and has pro-or anti-tumor effects. Studies on tumor cells have found that GSDMB is highly expressed in breast cancer, gastric cancer, liver cancer, cervical cancer and colon cancer cells. Therefore, scholars believe that GSDMB may be involved in cancer progression and metastasis as an oncogene. This article reviews the role of GSDMB in various malignant tumors, in order to provide new ideas for the clinical diagnosis, treatment and prognosis of tumors.