膜性肾病临床治疗标准的研究进展

Research Progress on Clinical Treatment Standards for Membranous Nephropathy

膜性肾病是临床上较为常见的慢性肾小球疾病病理类型,分为特发性膜性肾病和继发性膜性肾病,病理特征是免疫复合物的沉积导致肾小球基底膜增厚。该疾病病理机制较为复杂,目前尚不明确。近年来,随着肾活检人数的增加,膜性肾病的发病率也呈上升趋势。任何年龄段均可发作,但大多数患者年龄集中在40~60岁之间,男性比女性更多见。约30%的患者临床症状会伴有镜下血尿,一般无肉眼血尿。本文拟对近来膜性肾病的临床治疗方案新认识做一综述。Membranous nephropathy is a common pathological type of chronic glomerular disease in clinical practice, divided into idiopathic membranous nephropathy and secondary membranous nephropathy. The pathological feature is the deposition of immune complexes leading to thickening of the glomerular basement membrane. The pathological mechanism of this disease is relatively complex and currently unclear. In recent years, with the increase of the number of renal biopsy, the incidence rate of membranous nephropathy is also on the rise. It can occur at any age, but most patients are concentrated between the ages of 40~60, with males more common than females. About 30% of patients have clinical symptoms accompanied by microscopic hematuria, generally without gross hematuria. This article aims to review the new understanding of recent clinical treatment strategies for membranous nephropathy.