DNA甲基化在外周T细胞淋巴瘤中的研究进展

Advances in DNA Methylation in Peripheral T Cell Lymphoma

外周T细胞淋巴瘤是一组罕见的强侵袭性的非霍奇金淋巴瘤,绝大部分目前治疗效果欠佳。近些年的证据表明表观遗传失调对于PTCL的发生发展起着驱动作用,特别是DNA甲基化。已发现在PTCL中存在DNA甲基化异常以及DNA甲基化修饰酶DNMT、TET、IDH的频繁突变,且与患者不良预后相关。随着对PTCL基因组学认识的深入,DNA甲基化作为表观遗传学的一个重要组成部分,有望为治疗PTCL提供新方向。Peripheral T-cell lymphoma (PTCL) is a group of rare, aggressive non-Hodgkin’s lymphomas, and most of them have poor treatment outcomes. Recent evidence suggests that epigenetic dysregulation plays a driving role in the occurrence and development of PTCL, especially DNA methylation. Abnormal DNA methylation and frequent mutations of DNA methylation modification enzyme DNMT, TET, and IDH have been found in PTCL, which are associated with poor prognosis of patients. With the deepening understanding of the genomics of PTCL, DNA methylation, as an important component of epigenetics, is expected to provide new directions for the treatment of PTCL.