骨关节炎中的信号通路

Signalling Pathways in Osteoarthritis

骨关节炎(OA)是最常见的疾病之一,其影响超过10%的人口,造成了巨大的社会经济负担。骨关节炎的病理改变累及整个关节,由多种类型的组织和细胞组成,如软骨退化、软骨下骨增厚、骨赘形成、滑膜炎症和肥大、韧带变性。关节的稳态由一个复杂的信号通路网络来调节合成代谢和分解代谢事件,信号通路网络的失调会对多个关节组织的结构和功能产生负面影响,最终导致OA的发生和进展。在这篇综述中,我们将讨论Hedgehog、Wnt/β-catenin、TGFβ和NF-κB这四种信号通路目前在OA领域的研究现状。Osteoarthritis (OA) is one of the most common diseases, affecting more than 10 percent of the population and causing a huge socio-economic burden. The pathological changes of osteoarthritis involve the entire joint and consist of several types of tissues and cells, such as cartilage degeneration, subchondral bone thickening, bone redundancy formation, synovial inflammation and hypertrophy, and ligament degeneration. Joint homeostasis is regulated by a complex network of signalling pathways that regulate anabolic and catabolic events, and dysregulation of the signalling pathway network can negatively affect the structure and function of multiple joint tissues, ultimately leading to the onset and progression of OA. In this review, we will discuss the current state of research in OA on four signalling pathways, Hedgehog, Wnt/β-catenin, TGFβ and NF-κB.