呼出气一氧化氮检测与慢性阻塞性肺疾病的相关性研究进展

Research Progress on the Correlation between Exhaled Nitric Oxide Detection and Chronic Obstructive Pulmonary Disease

目的:本文对呼出气一氧化氮检测与慢性阻塞性肺疾病的相关性进行系统综述,以期为本病相关研究的开展提供参考。方法:本文通过以“慢性阻塞性肺疾病、呼出气一氧化氮、气道炎症、嗜酸性粒细胞、肺功能、吸烟、糖皮质激素”等为关键词,检索2016年至2024年期间中国知网、万方、维普、PubMed数据库中相关文献,并进行归纳总结。结果:呼出气一氧化氮检测作为一种操作方便、可重复性高、非侵入性的检测方法,有助于反映气道炎症程度、预测慢阻肺患者急性加重的风险、辅助和鉴别诊断慢阻肺、预测激素治疗效果和评估预后。结论:FeNO检测在一定程度上有助于慢阻肺患者的病情评估、临床诊疗以及预后,具有较大的临床意义,值得推广使用。Objective: To systematically review the correlation between fraction of exhaled nitric oxide detection and chronic obstructive pulmonary disease, in order to provide reference for the development of related research on this disease. Methods: Using “chronic obstructive pulmonary disease, fraction of exhaled nitric oxide, airway inflammation, eosinophils, lung function, smoking, glucocorticoids” as keywords, the relevant literatures in CNI, Wanfang, VIP and PubMed databases from 2016 to 2024 were searched and summarized. Results: Fraction of exhaled nitric oxide, as a convenient, reproducible and non-invasive test, can help to reflect the degree of airway inflammation, predict the risk of acute exacerbation in patients with COPD, assist and differentiate the diagnosis of COPD, predict the effect of hormone therapy, and evaluate prognosis. Conclusion: Fraction of exhaled nitric oxide detection is helpful to the assessment, clinical diagnosis, treatment and prognosis of COPD patients to a certain extent, which has great clinical significance and is worth promoting.