NEK6与肿瘤关系的研究进展

Research Progress on the Relationship between NEK6 and Tumor

人类NIMA相关激酶(NIMA-related kinases, NEK)是一组在人类细胞中表达的与NIMA同源的蛋白激酶,它们通常在细胞周期的调控中扮演着重要的角色。目前在人类基因组中已经鉴定出NEK1到NEK11等多个成员,其中人类NIMA相关激酶6 (Human NIMA-related kinases 6, NEK6)正是其中的重要成员之一。NEK6在动物细胞中普遍表达,其主要位于细胞核内,是一种多功能细胞调控因子,它不但可以影响细胞周期的进程和细胞的稳定性,同时还可以作为信号转导因子参与调控多种信号转导通路。随着分子生物学技术的不断发展以及医疗的进步,NEK6与各种肿瘤发生发展的关系也逐步引起了公众的广泛关注。截至目前的研究表明:多种恶性肿瘤的生物学行为显著受到NEK6异常表达的影响,本文将归纳并总结NEK6参与调控乳腺癌、胃癌、肝癌及肾细胞癌等恶性肿瘤的机制并进行综述。Human NIMA-related kinases (NEK) are a group of protein kinases homologous to NIMA expressed in human cells, which generally play an important role in the regulation of the cell cycle. Several members of NEK1 to NEK11 have been identified in the human genome, among which human NIMA-related kinases 6 (NEK6) is one of the important members. NEK6 is widely expressed in animal cells, mainly located in the nucleus, and is a multifunctional cell regulator, which can not only affect the progress of the cell cycle and the stability of cells, but also participate in the regulation of a variety of signal transduction pathways as a signal transduction factor. With the continuous development of molecular biology technology and medical advancement, the relationship between NEK6 and the development of various tumorigenesis has gradually attracted extensive public attention. This article will summarize the mechanism of NEK6 in the regulation of breast cancer, gastric cancer, liver cancer and renal cell carcinoma.