中性粒细胞和淋巴细胞比值与宫颈癌放疗过程中放射性肠炎的相关性

Correlation between Neutrophil to Lymphocyte Ratio and Radiation Enteritis during Radiotherapy for Cervical Cancer

本研究旨在分析中性粒细胞与淋巴细胞比值(NLR)是否与宫颈癌患者的放射线肠道炎症(RE)有关联。我们选择的是从2020年10月至2021年7月期间接受了放射疗法的39名宫颈癌病人作为我们的研究群体,并根据其NLR的最优切割点将其划分为低NLR组和高NLR组。分别根据RTOG标准和GSRS量表对患者RE严重程度进行评估,将RTOG分级为1级定义为轻度RE,2级定义为中度RE,3级和4级的定义为严重RE。分析放疗前NLR水平与宫颈癌患者放疗过程中RE严重程度之间的联系。经过对ROC曲线的分析后,我们确定了放射治疗前的NLR的最优切割点数值是2.76。基于RTOG与GSRS评分系统的结果显示,高NLR的患者比那些较低NLR的患者更易发生严重的RE,并且他们的GSRS评分也明显更高(P The aim of this study is to explore the connection between the neutrophil to lymphocyte ratio (NLR) and radiation enteritis (RE) in patients undergoing radiation therapy for cervical cancer. 39 patients with cervical cancer who received radiotherapy between October 2020 and July 2021 were analyzed in this study. They were categorized into low and high NLR groups based on the optimal NLR cut-off value in the ROC curve. The assessment of patients’ RE severity was determined using the RTOG criteria (Radiation Therapy Oncology Group) criteria and GSRS (Gastrointestinal Symptoms Rating Scales) respectively, and grade 1 of RTOG was defined as mild RE, grade 2 as moderate RE, grade 3 and 4 as severe RE. In this study, we examined how the level of NLR prior to radiotherapy is linked to the intensity of radiation esophagitis in cervical cancer patients. The ROC curve analysis revealed that the ideal threshold for NLR before radiotherapy was determined to be 2.76. The RTOG criteria and GSRS scale revealed that the high NLR group had a greater proportion of patients with severe RE than their low NLR counterparts, as well as an increased GSRS score (all P < 0.05). Clinical stage, N stage, and NLR level were found to have significant associations with the development of moderate-severe RE in logistic univariate regression analysis. However, in logistic multivariate regression analysis, it was revealed that the independent risk factors for moderate-severe RE occurrence were NLR level and N stage. NLR was determined to have diagnostic value for predicting moderate-severe RE in cervical cancer patients undergoing radiotherapy (P < 0.05). NLR is associated with the severity of RE during radiotherapy for cervical cancer patients, and it shows a certain predictive value for the occurrence of moderate-severe RE.