基于肠道菌群探讨中医药治疗溃疡性结肠炎的研究进展

Research Progress in the Treatment of Ulcerative Colitis with Traditional Chinese Medicine Based on Intestinal Flora

溃疡性结肠炎是一种累及结直肠的慢性复发性炎症性肠病,其发病机制尚未明确,现有大量研究表明,肠道菌群失衡与溃疡性结肠炎发生发展密切相关。目前西医治疗多采用5-氨基水杨酸、激素、免疫抑制剂等药物,短期内疗效明显,然而长期使用疗效欠佳,并伴随多种不良反应,因此寻求防治溃疡性结肠炎的新方法迫在眉睫。近年来,随着对传统中医药的深入探索,众多研究表明,中药单体及中药复方可以通过多靶点、多环节、全方位调节肠道菌群进而降低肠黏膜炎症反应,干预溃疡性结肠炎的进展,未来有望在提高疗效、改善患者生活质量、降低复发率等方面取得更大进展,成为防治溃疡性结肠炎的新热点。基于此,本文通过综述肠道菌群与溃疡性结肠炎的相互关系以及中医药调控肠道菌群治疗溃疡性结肠炎的研究进展,以期为临床治疗该病提供新思路。Ulcerative colitis is a chronic recurrent inflammatory bowel disease involving the colon and rectum. Its pathogenesis is not well understood. A large number of studies have shown that intestinal flora imbalance is closely related to the occurrence and development of ulcerative colitis. At present, Western medicine mainly uses 5-amino-salicylic acid, hormones, immunosuppressants and other drugs. The short-term effect is obvious, but the long-term effect is not good, and accompanied by a variety of adverse reactions. Therefore, it is urgent to seek a new variety of adverse reactions. Therefore, it is urgent to seek a new method to prevent ulcerative colitis. In recent years, with the in-depth exploration of traditional Chinese medicine, many studies have shown that Traditional Chinese Medicine monomer and compound can regulate intestinal flora in a multi-target, multi-link and all-round way, thus reducing intestinal mucosal inflammation and interfering with the progression of ulcerative colitis. In the future, it is expected to make greater progress in improving the curative effect, improving the quality of life of patients, and reducing the recurrence rate, and become a new hot spot in the prevention and treatment of ulcerative colitis. Based on this, this paper reviews the relationship between intestinal flora and ulcerative colitis and the research progress of Traditional Chinese Medicine regulation of intestinal flora in the treatment of ulcerative colitis, in order to provide new ideas for clinical treatment of this disease.