脂肪因子Apelin与妊娠期糖尿病发病机制的研究进展

Advances in the Study of Adipokine Apelin and Pathogenesis of Gestational Diabetes Mellitus

妊娠期糖尿病(GDM)是最常见的围产期并发症之一,其发病机制尚未明确,可能是由肥胖、胰岛素抵抗(IR)及炎症反应等多因素共同作用的结果。Apelin作为新型脂肪因子,与肥胖、胰岛素抵抗及炎症反应关系密切,可能参与GDM的病理生理机制中。研究表明,Apelin具有降糖、改善胰岛素敏感性等作用,有望成为GDM治疗的新靶点。Gestational diabetes mellitus (GDM) is one of the most common perinatal complications. However, its pathogenesis is not clear, which may be the result of multiple factors such as obesity, insulin resistance (IR) and inflammatory response. As a novel adipokine, Apelin is closely related to obesity, insulin resistance and inflammation, and may be involved in the pathophysiology of GDM. Studies have shown that Apelin has the effects of reducing blood sugar and improving insulin sensitivity, and is expected to become a new target for GDM treatment.