导管消融术改善心房颤动患者肾功能受损的研究进展

Research Advances of Catheter Ablation Improving Renal Function Impairment in Patients with Atrial Fibrillation

心房颤动(Atrial fibrillation, AF)是最常见的持续性心律失常,慢性房颤可通过各种机制引起肾功能损伤,导致或加重慢性肾脏病(chronic kidney disease, CKD)。而CKD患者也常合并AF,二者之间有着密切的相关性。目前导管消融术已成为AF的一线治疗,在维持窦性心律、改善预后等方面较药物治疗更优。已有研究证实AF导管消融术后部分患者肾功能得到显著改善,但其中具体的关系尚不明确。本文就AF与CKD之间复杂的病理生理学相关性及AF导管消融延缓肾功能衰退的相关研究进行文献综述。Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Chronic AF, through various pathophysiological mechanisms, can adversely affect renal function, leading to the initiation or exacerbation of chronic kidney disease (CKD). The bidirectional relationship between CKD and AF is well-documented, with both conditions frequently coexisting. Presently, catheter ablation (CA) is considered the first-line treatment for AF, demonstrating superiority over pharmacological therapy in maintaining sinus rhythm and improving prognosis. Numerous studies have indicated that CA can significantly enhance renal function, although the precise mechanisms underlying this improvement remain to be fully elucidated.