肿瘤内微生物研究进展

Research Progress of Intratumoral Microbiota

肿瘤内微生物是肿瘤微环境的潜在组成部分,由于它们的低生物量和其他障碍,人们对其知之甚少。随着一些技术如组学和免疫学方法被用于肿瘤内微生物群的研究,曾经被认为是无菌的肿瘤组织实际上是多种微生物的宿主。微生物群可以通过粘膜破坏、邻近组织迁移和血液侵袭等方式定植肿瘤组织,从而影响肿瘤的生物学行为。对肿瘤内微生物群的更全面、更深入的认识不断涌现。本文就肿瘤内微生物的概念、发展历史、潜在来源进行了广泛的回顾,探讨了微生物在肿瘤诊断、预后以及抗肿瘤治疗中的临床作用,并对该领域未来可能的研究进行了展望。Intratumoral microbes are potential components of the tumor microenvironment that are poorly understood due to their low biomass and other barriers. As several techniques such as omics and immunological approaches have been used to study the intratumoral microbiota, tumor tissues, once considered sterile, are in fact host to a variety of microorganisms. Microbiota can colonize tumor tissues through mucosal destruction, adjacent tissue migration, and blood invasion, thus affecting the biological behavior of tumors. A more comprehensive and in-depth understanding of the tumor microbiome continues to emerge. This article reviews the concept, development history and potential sources of tumor microorganisms, discusses the clinical role of microorganisms in tumor diagnosis, prognosis and anti-tumor therapy, and prospects the possible future research in this field.