骨关节炎诊疗现状及研究进展

Current Status and Research Progress in Diagnosis and Treatment of Osteoarthritis

骨关节炎(Osteoarthritis, OA)是一种常见的慢性关节疾病,它的特点是关节软骨的进行性破坏和慢性疼痛的发展,构成了相当大的社会经济负担。通常体格检查(关节疼痛、变形)及影像学指标结果(包括边缘骨赘和关节间隙狭窄)有助于诊断,一些实验室检查及影像学方法可能对早期骨关节炎有识别作用。目前,其治疗目标主要是缓解与炎症和疼痛相关的OA症状。疾病修饰OA药物(DMOAD)、再生治疗、抗衰老药物或基因治疗是目前的研究热点及新兴战略,为骨关节炎的治疗提供了新的思路和途径。Osteoarthritis (OA) is a common chronic joint disease characterized by the progressive destruction of articular cartilage and the development of chronic pain, which constitutes a considerable socioeconomic burden. Physical examination (joint pain, deformity) and imaging index findings (including osteophytes at the edges and joint space stenosis) are usually helpful, and some laboratory tests and imaging methods may be useful for the identification of early osteoarthritis. At present, its therapeutic goal is mainly to relieve the symptoms of OA associated with inflammation and pain. Disease-Modifying OA Drugs (DMOAD), regenerative therapy, anti-aging drugs or gene therapy are the current research hotspots and emerging strategies, which provide new ideas and approaches for the treatment of osteoarthritis.