高良姜治疗胃溃疡作用机制的研究进展

Research Progress on the Mechanism of Action of Galangal in the Treatment of Gastric Ulcer

胃溃疡是消化科常见病、多发病,其治愈难度大,临床常用的西药不良反应较大,导致患者依从性较差,停药后会出现反跳现象。高良姜可以温胃止呕,散寒止痛,可以减少胃液量和总酸排出量,使胃蛋白酶活性降低,且其配合西药治疗,可以减少西药的不良反应,增加患者依从性,提高溃疡的愈合率。本文通过检索浏览CNKI、万方等数据库文献,综合论述高良姜及高良姜提取物、有效成分作用保护胃黏膜、促进溃疡愈合的作用机制,为进一步深入挖掘高良姜在治疗溃疡性疾病、消化系统疾病方面的其他应用价值提供思路。Gastric ulcer is a common and multiple disease in the department of digestion, and its cure is difficult. The adverse reactions of the commonly used Western medicine are large, leading to poor patient compliance and rebound phenomenon after discontinuation of treatment. Galangal can warm the stomach, stop vomiting, dispel cold, and relieve pain. It can also reduce the amount of gastric juice and total acid excretion and lower the activity of gastric protease, and when combined with Western medicine, it can reduce the adverse reactions of Western medicine and increase patient compliance, thereby improving the healing rate of ulcers. By searching and browsing literature databases such as CNKI and Wanfang, this paper comprehensively discusses the mechanisms of action of galangal and its extracts and effective components in protecting the gastric mucosa and promoting ulcer healing, providing ideas for further in-depth exploration of the other application values of galangal in treating ulcerative diseases and digestive system diseases.