生长分化因子15在心血管疾病中的诊疗作用及其研究进展

The Diagnostic and Therapeutic Roles of Growth Differentiation Factor 15 in Cardiovascular Diseases and Its Research Progress

目前,心血管疾病如动脉粥样硬化、心肌梗死、心脏肥大和心力衰竭等是全球主要的死亡原因,严重危害人类的生命安全,因此,心血管疾病的早期诊断、预后监测及治疗至关重要。近年来,生物标志物在心血管疾病患者的诊断和预后评估中具有越来越重要的临床价值。其中,生长分化因子15 (growth differentiation factor 15, GDF15)是一种新兴的心血管疾病生物标志物,是死亡率和不良预后的独立预测因子。许多基础研究还表明,GDF15在心血管疾病中发挥保护作用,可能具有潜在的治疗价值。本文就GDF15在心血管疾病中的诊疗作用及相关研究进展做一综述,旨在探索GDF15在心血管疾病诊断、预后监测和治疗中的应用前景。Currently, cardiovascular diseases (CVDs) such as atherosclerosis, myocardial infarction, cardiac hypertrophy, and heart failure are the leading causes of death globally, posing a serious threat to human life safety. Therefore, early diagnosis, prognosis monitoring, and treatment of CVDs are crucial. In recent years, biomarkers have become increasingly important in the diagnosis and prognosis assessment of patients with CVDs. Among them, growth differentiation factor 15 (GDF15) is an emerging biomarker for CVDs and an independent predictor of mortality and poor prognosis. Many basic research studies have also indicated that GDF15 plays a protective role in CVDs and may have potential therapeutic value. This article reviews the diagnostic and therapeutic roles of GDF15 in CVDs and related research progress, aiming to explore the application prospects of GDF15 in the diagnosis, prognosis monitoring, and treatment of CVDs.