银杏叶片治疗缺血性中风的Meta分析

Meta-Analysis of Ginkgo Biloba Leaves in the Treatment of Ischemic Stroke

目的:系统评价银杏叶片治疗缺血性中风的临床疗效及安全性。方法:运用系统评价方法,检索银杏叶片治疗缺血性中风的随机对照试验,筛选合格研究,评价纳入研究质量,采用异质性检验、Meta分析等方法统计相关数据。结果:24项研究符合选择标准,采用随机效应模型统计,纳入数据的总有效率,P Objective: To systematically evaluate the clinical efficacy and safety of ginkgo biloba leaves in the treatment of ischemic stroke. Methods: The randomized controlled trials of Ginkgo biloba leaves in the treatment of ischemic stroke were searched by systematic evaluation method, qualified studies were screened, the quality of the studies was evaluated, and the relevant data were collected by heterogeneity test and Meta-analysis. Results: 24 studies met the selection criteria. Using a random effects model for statistics, the total effective rate included in the data shows P < 0.00001. The combined RR (95% CI) from the random effects model is 1.21 (1.14, 1.28), and RD (95% CI) is 0.15 (0.11, 0.19), suggesting that the total effective rate of patients in the experimental group is significantly higher than that of the control group, and the difference between the two groups is statistically significant. Conclusion: The existing evidence shows that ginkgo biloba leaves are beneficial in improving the degree of neurological impairment of ischemic cerebrovascular disease, but ginkgo biloba leaves have the risk of adverse reactions such as abdominal pain, abdominal discomfort and systemic skin itching, but there are few such reports in clinic.