脂质代谢在脑胶质瘤中的研究进展

Research Progress of Lipid Metabolism in Brain Glioma

胶质瘤(Glioma)是指起源于神经胶质细胞的肿瘤,是中枢神经系统最常见的原发性恶性肿瘤,具有复发率高、预后差等特点,目前治疗方案主要以手术辅以放、化疗为主。代谢重编程是肿瘤的标志,作为三种主要物质代谢之一,脂质具有明显的影响。脂质代谢通过调节各种致癌信号途径参与肿瘤的发生、发育、侵袭和转移。为了进一步了解脂质代谢在胶质瘤细胞中所起到的作用,本文就脂质代谢与脑胶质瘤之间的关系及其相关机制作一综述,探讨脂质代谢在其发生发展中的作用和意义。Glioma, a tumor originating from glial cells, is the most common primary malignant tumor in the central nervous system, characterized by high recurrence rate and poor prognosis. Currently, surgery, radiotherapy and chemotherapy are the main treatment options. Metabolic reprogramming is a hallmark of tumors, and as one of the three major substances metabolized, lipids have a clear effect. Lipid metabolism is involved in the occurrence, development, invasion and metastasis of tumors by regulating various carcinogenic signaling pathways. In order to further understand the role of lipid metabolism in glioma cells, this article reviewed the relationship between lipid metabolism and brain glioma and its related mechanisms, and discussed the role and significance of lipid metabolism in its occurrence and development.