胆红素水平与冠心病关系的研究进展

Research Progress of Relationship between Bilirubin Level and Coronary Heart Disease

冠状动脉粥样硬化性心脏病(CHD)是一种常见的心血管疾病,随着人们社会生活水平的提高和饮食结构的改变,冠心病的发病率逐年增长,成为心血管系统疾病的最重要疾病之一。上世纪60年代初,美国完成了一项具有划时代意义的大型流行病学研究——Framingham研究,从此人们的认知中多了CHD危险因素这一重要概念,而胆红素(Bilirubin, BIL)属于其中较具代表性的一种,通过检测血清中BIL的浓度,可能对CHD的早期预测以及冠脉病变程度的评判有着极其重要的价值。一些学者认为BIL是冠心病的保护因素,但也有研究表明BIL与CHD的发生不相关甚至呈正相关,本文就BIL与CHD的关系做如下综述。Coronary artery atherosclerotic heart disease is a common cardiovascular disease. With the improvement of people’s social living standards and changes in dietary structure, the incidence of coronary heart disease has been increasing year by year, becoming one of the most important diseases in the cardiovascular system. In the early 1960s, a groundbreaking large-scale epidemiological study called the Framingham Study was completed in the United States. Since then, people have gained an important concept of CHD risk factors. Bilirubin (BIL) is one representative factor among them. By detecting the concentration of BIL in serum, it may have significant value for early prediction of CHD and evaluation of coronary artery lesions. Some scholars believe that BIL is a protective factor for coronary heart disease, but there are also studies showing that BIL is not related to or even positively correlated with CHD occurrence. This article provides a review on the relationship between BIL and CHD as follows.